STUDIES RELATED TO THE CLINICAL ASPECTS OF MALARIA Malaria is a complex condition that shows different manifestations in different parts of the world depending on some variables (Bin Mohanna et al. 2007). Anemia and splenomegaly were found to be significantly associated with malaria among asymptomatic schoolchildren in Hajr Valley, Hadramout (Bin Mohanna et al. 2007). Agina and Abd-Allah (1999) conducted a case-control study for the association of nitric oxide levels with the severity and outcomes of cerebral malaria in Yemeni hospitalized patients. The main clinical presentations in cerebral malaria patients were fever (76.4%), pallor (72.0%), hypoglycemia (67.4%), splenomegaly (60.5%), deep coma (39.5%). ), jaundice (18.6%), pulmonary edema (13.9%), subconjunctival hemorrhage (13.9%), severe anemia (53.5%) and hemoglobinuria (6.9%) during In patients suffering from Non-cerebral malaria clinical presentations were fever (83.8%), pallor (67.7%), splenomegaly (66.0%), jaundice (9.7%), severe anemia (51.6%), and hypoglycemia ( 3.2%). Serum nitric oxide level was higher in patients with cerebral malaria than in those without. In cerebral malaria, nitric oxide levels were very elevated in patients with deeper and longer-lasting coma, as well as in those who died of cerebral malaria, indicating its association with indices of disease severity and outcome in cerebral malaria patients. (Agina and Abd-Allah, 1999). Sheiban et al. (1998) studied severe acute renal failure secondary to falciparum malaria among children receiving antimalarial therapy and other supportive care, as well as peritoneal dialysis, admitted to the renal unit of Al-Thawra Hospital in Sana'a. In this study, it was concluded that significant differences were found between deceased children (43.8%) compared to surviving children with regards to age, plasma creatinine, plasma bilirubin, systolic and diastolic blood pressure, hemoglobin concentration, blood production urine and time since diagnosis. to postponement. However, gender, alanine aminotransferase level, degree of fever, plasma sodium or potassium levels were not statistically different between these two groups (Sheiban et al. 1998). The author found that prior immunity, as indicated by the presence of splenomegaly, was associated with a better prognosis both in terms of lower mortality and less hemodynamic disturbance evident in older children due to prior exposure to malaria infection, and therefore the development of immunity (Sheiban et al. 1998). It is important to note that malaria has been reported to be the cause of 5.9% of chronic renal failure in patients undergoing regular hemodialysis in Hadramout governorate (Badheeb 1998). Recently, Al Rohani et al. (2011) reported that malaria is the most common infectious disease causing acute renal failure (ARF) in Yemeni patients.