DISCUSSIONPyogenic infections are characterized by severe local inflammation, usually with the development of pus. It is an incursion and growth of pathogenic microorganisms in a body part or tissue, which can produce subsequent tissue injury and the development of full-blown disease through a variety of cellular or toxic mechanisms, generally caused by one of the bacteria of pigeons. Infectious microorganisms such as Staphylococcus, Streptococcus, Neisseria, Klebsiella, Proteus, Pseudomonas (Sarala et al., 2010), Escherichia coli, Salmonella typhi, Mycobacterium tuberculosis (Singh et al., 2013) and some other species of pathogenic bacteria usually produce pus. This is usually a source of infection to others and transmission may be due to direct contact with through forms. To cure the problem antibiotic is the main option. Choosing an effective antimicrobial agent for a microbial infection requires awareness of the potential microbial pathogen, understanding the pathophysiology of the infectious process, and understanding the pharmacology and pharmacokinetics of intended therapeutic agents (Kelwin, 1999). aimed to isolate and identify bacteria from clinical pus samples obtained from the patient suspected of pyogenic infection and to detect the drugs of choice against the infection and also this study was conducted to determine the socioeconomic characters and characters related to pyogenic infection associated with pathogenic infection among patients in a tertiary care center in Salem, Tamil Nadu, India. Goswami et al. (2011) reported that the predominant organisms isolated from wounds were Staphylococcus aureus 48 (26.23%) Klebsiella pneumoniae 38 (20.77%), Pseudomonas aeruginosa ...... middle of paper ...... d . In the present study, Klebsiella spp. the isolates were resistant to Ampicillin, Rifampicin, Erythromycin and Streptomycin, Cefotaxime and Tetracycline, Amikacin, Cefuroxime and Imipenem. P. aeruginosa isolates from the pyogenic abscess were resistant to all antibiotics tested except imipenem. Proteus spp. isolates were resistant to cefotaxime, ampicillin, tetracycline, rifampicin, erythromycin, streptomycin, amikacin, and gentamicin. E. coli isolates were resistant to ampicillin, tetracycline, rifampin, erythromycin and streptomycin, cefotaxime, ceftriaxone, and amikacin. The frequency of resistance to single and multiple drugs is frighteningly high. This could be a mirror image of the misuse of antimicrobials, lack of laboratory diagnostic services, or unavailability of guidelines related to drug selection. Therefore, a balanced use of drugs should be achieved.