Nanoemulsions/submicron emulsions (PMI)/mini-emulsions are thermodynamically stable transparent or translucent dispersions of oil and water stabilized by an interfacial film of surfactant and cosurfactant molecules having smaller globular dimensions at 100 nm. Recently, nanoemulsions are often used for the administration of vaccines, DNA-encoded drugs, antibiotics, cosmetic and topical preparations, and are administered through various routes such as oral, pulmonary, intranasal, ocular and transdermal, etc. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Nanoemulsion, classified as a multiphase colloidal dispersion, is generally characterized by its stability and clarity. The dispersed phase typically comprises small particles or droplets, with a size range of 5 nm to 200 nm, and has a very low oil/water interfacial tension. Because the droplet size is less than 25% of the wavelength of visible light, nanoemulsions are transparent. The nanoemulsion forms readily and sometimes spontaneously, generally without high-energy inputs. In many cases a co-surfactant or co-solvent is used in addition to the surfactant, oil phase and aqueous phase. Nanoemulsions are defined as isotropic, thermodynamically stable, transparent or translucent dispersions of oil and water stabilized by an interfacial film of surfactant molecules with droplet sizes of 20–500 nm. Nanoemulsions are also called miniemulsions, ultrafine emulsions and submicron emulsions. Phase behavior studies have shown that droplet size is governed by the structure of the surfactant phase (bicontinuous or lamellar microemulsion) at the temperature- or composition-induced inversion point. Studies on the formation of nanoemulsions by the phase inversion temperature method have shown a relationship between the minimum droplet size and complete solubilization of the oil in a biocontinuous microemulsion phase regardless of whether the equilibrium of the initial phase is single-phase or multiphase. Nanoemulsions are isotropic, thermodynamically stable transparent (or translucent) systems of oil, water, surfactant and co-surfactant with a droplet size usually between 20 and 200 nm. Their long-term stability, ease of preparation (spontaneous emulsification), and high solubilization of drug molecules make it a promising tool for drug delivery. Recently, much attention has been focused on colloidal drug delivery systems such as microemulsions, solid lipid nanoparticles, and liposomes for topical drug delivery due to low side effects, high bioavailability, good patient compliance, etc. Nanoemulsions (also called mini emulsions, ultrafine emulsions or submicron emulsions) used for parenteral nutrition are polydisperse, isotropic, kinetically stable, but thermodynamically unstable systems of the oil-in-water (O/W) type, which should be sterile and pyrogenic. Three types of nanoemulsions are most likely to form depending on the composition: Oil in water Nanoemulsion where oil droplets are dispersed in the continuous aqueous phase; Water in oil Nanoemulsion in which water droplets are dispersed in the continuous oil phase; Bi-continuous nanoemulsion, in which microdomains of oil and water are interdispersed within the system. In all three types of nanoemulsions, the interface is stabilized by an appropriate combination of surfactants and/or co-surfactants. The difference.