IntroductionDisease!!!!! Illness!!!! Illness!!!! Living on this earth we are exposed to many different infectious diseases. Hepatitis E is a very serious liver disease caused by the hepatitis E virus (HEV) that usually causes an acute infection. (http://www.cdc.gov/hepatitis). It's safe to say that hepatitis E does not lead to a chronic infection according to the CDC. In this research paper I will identify the causal agent, geographic distribution, transmission, clinical characteristics, diagnosis, treatment and control measures of this serious liver disease. Key facts about hepatitis E may include: • There are 20 million hepatitis E infections, more than 3 million acute cases of hepatitis E, and 57,000 hepatitis E-related deaths each year. • Hepatitis E is found in all the world, but the prevalence is higher in eastern regions and southern Asia• Hepatitis E is generally self-limiting, but can develop into fulminant hepatitis and is transmitted via the fecal-oral route, mainly through contaminated water.• China has produced and licensed the first vaccine to prevent hepatitis E virus infection, although it is not yet available globally. The etiological agent The etiological agent of hepatitis E is the hepatitis E virus (HEV). According to my research, the virus originated from the feces of a volunteer infected orally by faces of suspected cases of non-A and non-B hepatitis (Balayan et al. 1983). Hepatitis E virus is a single, undeveloped, positive-sense virus. The stranded ribonucleic acid (RNA) virus has a size of approximately 27-30 nm (veterinami medicina 52, 2007) (HEV) infections spread via the fecal-oral route and cause sporadic and epidemic acute viral hepatitis throughout the world, usually through contaminated water supplies. (Vasickova et al, 200...... half of paper ...... was first observed and described in 1983 (Balayan et al., 1983). Since then the virus has been extensively studied. After a long effort to assign this virus to a taxonomic class, the virus was classified into the genus Hepevirus, family Hepeviridae in 2004 (Emerson et al., 2004; http://www.ncbi.nlm.nih.gov/ ICTVdb/Ictv /fs_hepev.htm). Anti-HEV (or viral RNA) antibodies have not only been found in humans, but also in various animal species (Arankalle et al., 1994,2001; Favorov et al., 1998 ).Bibliography( http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_hepev.htm).Who.int/Hepatitis E1 http://www.cdc.gov/hepatitis/HEV/HEVfaq.htm2 .http://www.who.int/mediacentre/factsheets/fs280/en/3 http://www.rightdiagnosis.com/h/hepatitis_e/intro.htm4 http://www.vri.cz/docs/vetmed /.52-9-365.pdf5 http://hepatitis.emedtv.com/hepatitis-e/hepatitis-e.html